We’re looking for talented, vision-driven partners to collaborate on building the next generation of biotechnology.
Next Generation Biochips
Enabling the next paradigm shift in DNA Sequencing and proteomics.
Nanogami’s Technology is currently the only available option to accurately place single molecules at scale
With DNA Origami probes you can place groups of molecules - and design an entire world of new functionality
Our DNA Origami probes can be customised and mass-produced easily—to fit right into any chip structure
Welcome to the nano revolution
Whereas computer chips process digital information, biochips process biological information. For example, researchers and physicians often care about the presence or absence of molecules which could be indicative of disease or of other health conditions. Because biochips allow processing many molecules in parallel, they underpin a rapidly growing number of technical and medical applications. As the number and type of applications grow, so do the expectations and demands on the performance of biochips. How can we further increase throughput, i.e., how can we detect more molecules in parallel and per unit time? How can we improve specificity and sensitivity? Can we even detect single molecules? How can we reduce reagent consumption (and thus cost)? How can we make biochip fabrication itself more efficient and less expensive?
At nanogami, we believe we have an answer to all these questions. We specialize in a fabrication technology called DNA origami, which enables us to build extremely miniaturized breadboards from DNA molecules. We use these breadboards to organize and arrange individual molecules in ways that facilitate their detection. Each molecule then becomes a sensor for a condition of interest. For example, antibodies can detect antigens, nucleic acids can detect other nucleic acids, and so on and so forth. In addition, we place nanoscale antennas or other features in the vicinity of the sensor molecules on the DNA origami breadboards to amplify the signal generated from each sensor. Our sensor breadboards are then placed and arranged in ultra-high density and user-defined patterns on solid surfaces to create the actual multiplexed biochip, which can be read-out via direct imaging or by other means. As a result, our biochips can detect and analyze biological molecules faster, more efficiently, and cheaper than ever before.
Rather than focussing on one specific biochip architecture, our vision is to enable and empower the entire life-science discovery and diagnostics industry, by providing an industry-spanning horizontal biochip framework that can be adapted and customized to target specifications, whether for genomics, transcriptomics, or proteomics - or everything at the same time, on one and the the same chip.
How it works
A nano structure is made using our proprietary DNA origami technology.
One or multiple molecules are bound to the DNA origami nanostructure.
The nanostructure populates a Biochip well, with complete accuracy.
The nanostructure dissolve, perfectly placing the molecules in the biochip wells.
Our leadership team
In our commitment to achieving the future we envision, we are determined to assemble the most talented minds from across the globe.
Nicola is serial entrepreneur with a background in molecular biology. She fosters innovative ventures as Innovation Manager at Germany Federal Agency of Disruptive Innovation. At Nanogami she is guiding the organisation as CEO.
Jean-Philippe investigated the assembly process of DNA origami nanostructures experimentally and theoretically in his Ph.D at the Technical University of Munich. He is a DNA-origami designer and CSO at Nanogami.
Hendrik is a professor for biophysics at the Laboratory for Biomolecular Design at the Technical University of Munich. He is a leading researcher in DNA nanotechnology and has made key discoveries in the design, production, and use of DNA nanostructures. He is active as a scientific advisor at Nanogami.
A team of pioneers
Want to make an impact in revolutionizing the future?
Our five year plan
Backed by SPRIN-D, an organization that supports breakthrough innovations with financial backing and know-how so that they can successfully bring their inventions to market.
We are perfecting our molecule placement technology to flawlessly place molecule groups on commonly used chip surfaces. Our goal is to make our technology fit right into our partner’s systems, not the other way around.
We will create a toolbox of functional molecule groups that will revolutionize the way we sequence DNA or study proteomes. We aim to help our partners efficiently and at scale without reinventing the wheel in every project.
We will start to integrate our placed molecules into semiconductor devices. Our goal is to enable chip readouts by off-the-shelf digital computers, without expensive microscopes.
We will start working with strategic partners on prototypes for actual DNA Origami Chips with the aim to build useful products
We will enable production at scale by developing reproducible and precise production technologies that allow automation and prompt distribution
The first DNA Origami Chip demonstrates our possibilities and inspires new ideas how we can use single molecule placement to build new functionality